ea0094p66 | Metabolism, Obesity and Diabetes | SFEBES2023
Crastin Ana
, S. Martin Claire
, Sagmeister Michael
, V. Adcock Holly
, R. Adams Holly
, Raza Karim
, Filer Andrew
, J. A. Moakes Richard
, M. Grover Liam
, S. Hardy Rowan
Intra-articular (IA) glucocorticoids (GCs) injections are effective in controlling joint inflammation but limited by short duration of action and off-target side effects. Gellan sheared hydrogels (SHs) area drug delivery vehicle, with unique thinning properties and enhanced release kinetics. We hypothesise that a combination of SHs and pre-receptor metabolism activated GCs provide slow-release drug delivery to target inflammation and minimise side-effects. We the release kinet...